The article presents the principles and methods of engineering disciplines of engineering in the process of design and construction of self-propelled work machines, in order to ensure favorable and safe working conditions; based on many years of research in the laboratories of the Department of Security of life and the creation of DSTU discipline "Engineering Ergonomics", based on the priority principles of human factor, showing the methodological and technical development principles of comfortable workplace human-machine operator; it is considered prospects for improving the harmonic connection hardware and the human factor in the self-propelled machines, safety.